pentobarbital will minimize the level or outcome of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will reduce the level or result of guanfacine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Potent or moderate CYP3A4 inducers substantially le